Less sedating than
The difference is Zyrtec is more likely to cause sedation than Claritin.Zyrtec also has a quicker onset of action (one hour vs up to three hours for Claritin) but both last for 24 hours.
The most common side effect is a metallic after taste; however, this is more likely at higher dosages and tends to dissipate with continued use.
Zyrtec is 3.5 times more likely than Claritin to cause sedation, particularly when used at dosages higher than 10mg/day.
However, Zyrtec is still much less sedating than older antihistamines such as promethazine.
Zyrtec Vs Claritin: Side Effects and Interactions Claritin is unlikely to cause CNS side effects such as sedation, or confusion when used at dosages of 10mg/day.
Side effects may be more likely when used at higher dosages.
Studies have shown equal effectiveness for Zyrtec and Claritin for allergic rhinitis and urticaria.